Chromosomal Segregation Defects in Cancer Cells
Formation of Anaphase Bridges and Multipolar Spindles
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Genomic instability is a common phenomenon in cancer.The vast majority of cancers frequently exhibit grossstructural, chromosomal alterations such astranslocations, deletions, and amplifications. Thesechromosomal alterations may arise from errors duringcell division or repair of DNA damage. Of theseerrors, segregational defects such as anaphasebridges and multipolar spindles play a major role inchromosomal instability, leading to tumorigenesis.However, little is known about the mechanisticdetails on how these form. By reading this book, youwill gain insights into the background, terminologyand...
Genomic instability is a common phenomenon in cancer.
The vast majority of cancers frequently exhibit gross
structural, chromosomal alterations such as
translocations, deletions, and amplifications. These
chromosomal alterations may arise from errors during
cell division or repair of DNA damage. Of these
errors, segregational defects such as anaphase
bridges and multipolar spindles play a major role in
chromosomal instability, leading to tumorigenesis.
However, little is known about the mechanistic
details on how these form. By reading this book, you
will gain insights into the background, terminology
and underlying reasons causing these anomalies. While
the main emphasis is on how DNA repair proteins
potentially lead to anaphase bridges, the effects of
ionizing radiation on multipolar spindle formation is
also discussed. Readers working in cancer field,
especially those interested in errors in cell
division will greatly benefit from this book.
Moreover, the book should also please instructors
teaching cell biology with the quality of images
showing various defects of cells in mitosis.
The vast majority of cancers frequently exhibit gross
structural, chromosomal alterations such as
translocations, deletions, and amplifications. These
chromosomal alterations may arise from errors during
cell division or repair of DNA damage. Of these
errors, segregational defects such as anaphase
bridges and multipolar spindles play a major role in
chromosomal instability, leading to tumorigenesis.
However, little is known about the mechanistic
details on how these form. By reading this book, you
will gain insights into the background, terminology
and underlying reasons causing these anomalies. While
the main emphasis is on how DNA repair proteins
potentially lead to anaphase bridges, the effects of
ionizing radiation on multipolar spindle formation is
also discussed. Readers working in cancer field,
especially those interested in errors in cell
division will greatly benefit from this book.
Moreover, the book should also please instructors
teaching cell biology with the quality of images
showing various defects of cells in mitosis.
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