Chemical Biology, Selected Papers of H G Khorana (with Introductions)
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These selected papers illustrate the developments of the chemical synthesis of phosphate esters of biological interest (nucleotides and nucleotide coenzymes), of ribo- and deoxyribo- polynucleotides (RNA, DNA) and of the total synthesis of genes in the laboratory, including principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and bioenergetics (1979...
These selected papers illustrate the developments of the chemical synthesis of phosphate esters of biological interest (nucleotides and nucleotide coenzymes), of ribo- and deoxyribo- polynucleotides (RNA, DNA) and of the total synthesis of genes in the laboratory, including principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and bioenergetics (1979-1993) that led to the understanding of the mechanism of the biological proton pump, bacteriorhodopsin, a prototypic molecule for the seven helical transmembrane proteins.
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