CCN proteins in health and disease
Broschiertes Buch

CCN proteins in health and disease

An overview of the Fifth International Workshop on the CCN family of genes

Herausgegeben: Perbal, Annick; Takigawa, Masaharu; Perbal, Bernard
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The CCN family of genes currently comprises six secreted proteins (designated CCN1-6 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors.The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, ...