Bryophyllum pinnatum Ligands for Unlocking Neurodegeneration
Blockers of MAO-B and AChE
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This book explores the potential of Bryophyllum pinnatum ligands as promising treatments for Alzheimer's and Parkinson's diseases. Widely consumed as part of traditional medicine, these plants are known for their low toxicity. By targeting key enzymes like acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), Mr. Olugbogi Ezekiel A. conducts a comprehensive computer-aided drug design using Schrödinger Suite software. Through docking, ADMET screening, and MM/GBSA analysis, the research identifies potent compounds, including pinoresinol, as potential neuroprotective agents. The findings ...
This book explores the potential of Bryophyllum pinnatum ligands as promising treatments for Alzheimer's and Parkinson's diseases. Widely consumed as part of traditional medicine, these plants are known for their low toxicity. By targeting key enzymes like acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), Mr. Olugbogi Ezekiel A. conducts a comprehensive computer-aided drug design using Schrödinger Suite software. Through docking, ADMET screening, and MM/GBSA analysis, the research identifies potent compounds, including pinoresinol, as potential neuroprotective agents. The findings highlight the therapeutic promise of B. pinnatum ligands in combating neurodegenerative disorders with minimal toxicity concerns.
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