Brimonidine base-loaded Solid Lipid Nanoparticles for Ocular Delivery
Noha El-Salamouni
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Brimonidine base-loaded Solid Lipid Nanoparticles for Ocular Delivery

In-vitro, In-vivo Evaluation

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Using glyceryl monostearate or Precirol® ATO 5 as solid lipid in 4% w/w concentration in addition to 0.05% w/w Poloxamer® 188, as an emulsifier were optimum for entrapping the hydrophobic Brimonidine base. The prepared solid lipid nanoparticles formulations showed uniform, nanosized particles below 500 nm, suitable for ophthalmic application, of good entrapment efficiency and accompanied by a sustained Brimonidine base release, compared to both Brimonidine(TM) eye drops and Brimonidine dispersion. Glyceryl monostearate solid lipid nanoparticles formulation showed good corneal permeation and ...