BRAIN GLYMPHATIC SYSTEM and NEURODEGENERATIVE CONDITIONS

BRAIN GLYMPHATIC SYSTEM and NEURODEGENERATIVE CONDITIONS

A SYSTEM BY WHICH THE WASTING MOLECULE ARE REMOVED FROM THE VERTEBRATES BRAIN - Physiopathology

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The central nervous system (CNS) is the only organ system of the body which lacks its own waste clearance or lymphatic system, a system which helps in removal of metabolic byproducts and waste solutes. Although the brain plays its role in 25% metabolism of body and comprises only 2% of the total body mass, this high metabolic load needs a proficient system for the removal of waste solutes and for maintaining homeostasis of brain environment. Well-depicted components of waste removal comprise of perivascular fluid flow and phagocytic immune cell functions, nonetheless, the requirement for dynam...