Biomarkers of Brain Injury in Children-Potential Uses and Limitations
Jirí Zurek
Broschiertes Buch

Biomarkers of Brain Injury in Children-Potential Uses and Limitations

S100B, NSE, GFAP, NF-H, secretagogin and Hsp70

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Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Clinical examination has limited ability to assess injury severity or predict outcome. The identification of pathology- specific biomarkers can assist in the diagnosis and estimation of prognosis, and can serve as surrogate markers for monitoring the effectiveness of a treatment. Most of these biomarkers are mediators of responses to injury and subsequent cell damage or cell death. For patients with severe TBI, a biomarker may be helpful to predict which patients are likely to experience secondary insults and he...