Biological Reactive Intermediates
Broschiertes Buch

Biological Reactive Intermediates

Formation, Toxicity, and Inactivation

Herausgegeben: Jollow, David
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The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating se...