Bioinformatics for High Throughput Sequencing
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This book looks at all aspects of next generation sequencing data analysis. It offers guidelines for the comprehension of the main data analysis steps and provides new insights into existing software and inspiration to develop new applications.
Next generation sequencing is revolutionizing molecular biology. Owing to this new technology it is now possible to carry out a panoply of experiments at an unprecedented low cost and high speed. These go from sequencing whole genomes, transcriptomes and small non-coding RNAs to description of methylated regions, identification protein - DNA interaction sites and detection of structural variation. The generation of gigabases of sequence information for each of this huge bandwidth of applications in just a few days makes the development of bioinformatics applications for next generation sequencing data analysis as urgent as challenging.
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