Autoagglutination
Red blood cell, Blood serum, Antibody
Herausgegeben: Luther, Evander
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Autoagglutination represents clumping of an individual's red blood cells (RBCs or erythrocytes) by his or her own serum due to the RBCs being coated on their surface by antibodies.Autoagglutination is seen to occur in a type of immune mediated hemolytic anemia known as cold antibody hemolytic anemia . Here, the antibodies which act on the erythrocytes are active at temperatures below 30 degree C.The cold reacting antibody has maximal activity at 4 degree C and at this...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Autoagglutination represents clumping of an individual's red blood cells (RBCs or erythrocytes) by his or her own serum due to the RBCs being coated on their surface by antibodies.Autoagglutination is seen to occur in a type of immune mediated hemolytic anemia known as cold antibody hemolytic anemia . Here, the antibodies which act on the erythrocytes are active at temperatures below 30 degree C.The cold reacting antibody has maximal activity at 4 degree C and at this temperature hemolysis ,rupture of erythrocytes, is not activated. The antibodies are of the class of IgM in 85% of cases and in 15 % a subtype of IgG known as Donath-Landsteiner antibody. IgM molecules, being large, are able to form bridges across adjacent erythrocytes, thereby leading to agglutination. Autoagglutination can result in visible clumping of erythrocytes in the collection device. Automated cell counters may produce abnormal values as the agglutinated cells may be counted as single cells.
