ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION

SELF-EMULSIFIED DRUG DELIVERY SYSTEM

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Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient pr...