Asymmetric Membrane Capsule- An Osmotic Approach

Asymmetric Membrane Capsule- An Osmotic Approach

Formulation and Evaluation of Asymmetric Membrane Capsule Osmotic Pump of Gliclazide

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The aim of this study was to demonstrate that the asymmetric membrane capsule can be used to deliver a poorly water soluble drug with a pH sensitive solubility such as gliclazide. In order to obtain the desired delivery duration, the drug was solubilized with the use of a pH-controlling excipient. The capsule wall membrane was made by a phase inversion process, in which asymmetric membrane was formed on glass mold pins by dipping the mold pins into a coating solution containing a polymeric material followed by dipping into a quench solution. This study evaluates the influence of coating formul...