Arginase as a potential target in the treatment of Alzheimer¿s disease
Baruh PolisAbraham Samson
Broschiertes Buch

Arginase as a potential target in the treatment of Alzheimer¿s disease

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Arginase is the central enzyme of the urea cycle hydrolyzing L-arginine to urea and L-ornithine. Recent studies have identified arginase function in the brain and associated this enzyme with the the development of neurodegenerative diseases. Arginase represents a promising novel therapeutic target. Arginase inhibition may reverse amyloid driven neuronal dysfunction and prevent development of Alzheimer's disease.