Apoptosis induced by cytotoxic cells of the immune system
Sara Yasemin Demiroglu
Broschiertes Buch

Apoptosis induced by cytotoxic cells of the immune system

The role of heat shock protein 70 and sulphatases 1 and 2 in granzyme B-induced apoptosis

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Intracellular heat shock protein 70 (HSP70) belongs to the stress response system and can protect cells from different apoptotic stimuli. Extracellular HSP70 on the other hand can activate cells of the innate and adaptive immune system. Acute overexpression of intracellular HSP70 could even increase the susceptibility of melanoma cells to cytotoxic T-lymphocytes (CTLs) that use the granule-exocytosis pathway for killing (Dressel et al. 1999). To decipher the molecular pathway of this increased susceptibility to CTLs, the effect of the acute overexpression of HSP70 on gene expression was analys...