Antifungal Resistance: Mechanisms, Detection and Perspectives

Description of resistance mechanisms and control strategies for fungal infections

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The use of antifungal agents is essential in the treatment of mycoses, especially in immunocompromised patients. However, the rise in resistance is compromising treatment efficacy, due to genetic mutations, activation of efflux pumps, and biofilm formation. Faced with this challenge, it is crucial to strengthen epidemiological surveillance and improve detection methods. Prospects for control include optimizing combination therapies, developing new molecules targeting fungal virulence mechanisms, and promoting more rational use of antifungal agents to prevent the emergence of new resistances.