Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells
Valeria Frangione
Broschiertes Buch

Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells

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Vaccination with poorly or not immunogenic tumour cells failed to protect the host from a subsequent challenge in animal models. The mechanisms underlying the failure of these cells to sensitize the therapeutic T cells are not clearly understood, but the inability of the host T cells to recognize the cancer has been implicated. Previous works have shown that an highly aggressive murine mammary adenocarcinoma can be rejected by the host if genetically modified to express MHC class II genes upon transfection of the MHC class II transactivator, CIITA. MHC class II molecules are required for prese...