Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence
Eltayeb Ali
Broschiertes Buch

Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence

Gametocyte Prevalence and Drug Resistance following treatment of Uncomplicated Plasmodium falciparum Malaria

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We monitored post-treatment Plasmodium falciparum among patients treated with chloroquine (CQ) and Fansidar (SP) in a village in eastern Sudan. Parasites were examined on day0, day7, day14 and day21 during the transmission season. A further sample was taken 2 months later (day80) at the start of the dry season. Asexual forms and gametocytes were detected by microscopy,and reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect expression of gametocyte-specific proteins pfs25 and pfg377. Microscopic gametocytes increased significantly following CQ and SP treatment, reaching ...