Analysis of Multiple Longitudinal Outcomes and Multiplicity Adjustment
Han-Joo Kim
Broschiertes Buch

Analysis of Multiple Longitudinal Outcomes and Multiplicity Adjustment

Application of Quasi-Least Squares and Gatekeeping Strategies in Clinical Trials

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Clinical trials often involve multiple endpoints that are clinically meaningful to determine efficacy and safety of the investigational medicinal product. These multiple outcomes are often measured over scheduled and/or unscheduled visits which add complexity when analyzing these types of data. This book is developed specifically to deal with multiple longitudinal outcomes in the framework of generalized estimating equations and their post-hoc multiplicity adjustment for the control of familywise error rate. The book covers a recent development and its extension of quasi-least squares to the a...