An Immunotoxin for the Depletion of Autoreactive B Cells in MS
Sigrun Klandt
Broschiertes Buch

An Immunotoxin for the Depletion of Autoreactive B Cells in MS

Design, expression, and characterization of an autoimmunotoxin for the specific depletion of autoreactive B cells in multiple sclerosis

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The aim of the presented work was the design, production, and characterisation of a novel immunotoxin in the context of MS. Proteins were expressed in a prokaryotic and eukaryotic system, respectively. Stable producing 293T cell populations were established for the reference protein PLP that showed a good expression yield and a high purity after purification was obtained. This is the first time that a functional PLP fusion protein was expressed in 293T cells and purified from cell supernatant. The characterisation of the immunotoxin PLP-ETA comprised the verification of the functionality of th...