Amelioration of Testicular Toxicity of Enrofloxacin with Selenium

Amelioration of Testicular Toxicity of Enrofloxacin with Selenium

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The study assessed the ameliorative potential of selenium (Se) against enrofloxacin-induced testicular toxicity in Wistar rats. Enrofloxacin was administered at the dose of 20 mg and 80 mg/ kg body weight. Two more groups of rats were co-administered with the supranational level of Se in addition to enrofloxacin treatment as above. Enrofloxacin treatment resulted in decreased total sperm count and viability and increased sperm abnormalities. Testicular histopathology revealed enrofloxacin-induced dose-dependent dysregulation of spermatogenesis and the presence of necrotic debris in seminiferou...