Adult celiac disease and associated autoimmune diseases

Adult celiac disease and associated autoimmune diseases

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Celiac disease (CD) is an autoimmune inflammatory enteropathy, caused by one of the protein fractions of gluten (food antigen), gliadin (a protein contained in wheat, rye and barley) and which occurs in genetically predisposed subjects [1,2,3]. Its pathogenesis results from the interaction between genetic, immunological and environmental factors which, through the intervention of the human leukocyte antigen (HLA) class II genes (encoding the HLA-DQ2 molecule, and those encoding the HLA-DQ8 molecule) induce an immune response in the intestinal mucosa leading to villous atrophy resulting in mala...