Absorption 2e
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This book explains how to examine a compound's pharmaceutical properties, emphasizing oral absorption, detailing different physicochemical methods and how to interpret results for analyzing drug candidates. Now in a new edition, this updated volume now includes more case examples, more entries into properties data tables, updated references, and extensive compilations of solubility, permeability, and pKas. With over 600 references and 100 drawings, this book is well-suited for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.
Explains how to perform and analyze the results of the latest physicochemical methods
With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates.
This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:
Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group
Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded information and methods to support pKa determination
New examples explaining the treatment of practically insoluble test compounds
Additional case studies demonstrating the use of the latest physicochemical techniques
New, revised, and expanded database tables throughout the book
Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book.
This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.
With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates.
This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:
Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group
Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier
Expanded information and methods to support pKa determination
New examples explaining the treatment of practically insoluble test compounds
Additional case studies demonstrating the use of the latest physicochemical techniques
New, revised, and expanded database tables throughout the book
Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book.
This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.
