A Handbook for Dna-Encoded Chemistry
Theory and Applications for Exploring Chemical Space and Drug Discovery
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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. The book is comprised of chapters summarizing practical methods, theoretical analysis and summary reviews - detailing an approach differing from classical approaches like high throughput screening, offering attractive alternatives to resource- and cost-intensive corporate chemical libraries for screening and drug lead discovery. Despite many publications on various results from laboratories specializing in the synthesis of hit finding of DNA-encoded chemistry that have been published since 1992, there has been no technical handbook offering this level of detail.
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
Helps chemists generate and screen novel chemical libraries of large size and quality
Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery
Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
Helps chemists generate and screen novel chemical libraries of large size and quality
Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry - synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
Shows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discovery
Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
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