Gebundenes Buch

5-HT2C Receptors in the Pathophysiology of CNS Disease

Beschreibung

Part of Springer's "The Receptors," series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors' therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson's disease, Prader-Willi Syndrome, Alzheimer's disease and epilepsy.

Produktdetails

• The Receptors 22
• Verlag: Humana / Humana Press / Springer, Berlin
• Artikelnr. des Verlages: 12177820, 978-1-60761-940-6
• 2011
• Seitenzahl: 572
• Erscheinungstermin: 1. Dezember 2010
• Englisch
• Abmessung: 241mm x 160mm x 34mm
• Gewicht: 978g
• ISBN-13: 9781607619406
• ISBN-10: 1607619407
• Artikelnr.: 30655584

Rezensionen

From the reviews:

"The book is well presented with good use of diagrams ... . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. ... In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite." (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)