5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents

5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents

Synthesis of New Substituted Anticancer Agent Part I

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In search of new anticancer agents we have reported the synthesis of some 1,3,4-thiadiazoles. While designing target molecules, we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other's. Furthermore also characterized and confirmed by IR, 1H-NMR, and Mass spectral. For anticancer activity, all the selected compounds were submitted to ...