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Hypertension is one of the primary risk factors for heart disease and stroke, the leading causes of death worldwide. Telmisartan is BCS class II, anti-hypertensive drug.The aim of present work was to develop a Telmisartan nanosuspension for faster onset of action which is essential in hypertension condition. In the present work nanosuspension is prepared by media milling method. Zirconium oxide beads are used as milling media. The optimization was done using 3level3 factor full factorial design.The optimized batch shown particle size is 356 nm,Zeta potential -8.3 and % drug release after 10 min is 64.20%.