Polymorphism - the multiplicity of structures or forms - is used in many disciplines. In chemistry it refers to the existence of more than one crystal structure for a particular chemical substance. The last two decades of the 20th century witnessed a sharp increase in the interest in polymorphic systems, as an intrinsically interesting phenomenon and as an increasingly important component in the development and marketing of a variety of materials based on organic molecules. As a result, every pharmaceutical, agrochemical and specialist chemical company needs "polymorphism know-how", so as to…mehr
Polymorphism - the multiplicity of structures or forms - is used in many disciplines. In chemistry it refers to the existence of more than one crystal structure for a particular chemical substance. The last two decades of the 20th century witnessed a sharp increase in the interest in polymorphic systems, as an intrinsically interesting phenomenon and as an increasingly important component in the development and marketing of a variety of materials based on organic molecules. As a result, every pharmaceutical, agrochemical and specialist chemical company needs "polymorphism know-how", so as to be aware of the compounds they sell and of patent issues. Edited by one of the leading experts in the field, this up-to-date handbook fills a need by emphasizing exactly why solid-state issues are important. It demonstrates which approaches should be taken to avoid problems and to exploit the opportunities offered by solid-state properties in the pharmaceutical, agricultural and fine chemical industries. With its practical approach, this is at once a guideline for development chemists just entering this rapidly expanding field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.
After gaining his PhD in physical chemistry from Basel University, Switzerland, Rolf Hilfiker did his postdoc at Stony Brook, USA. He returned to Basel as a research fellow, initially at the university and then at Ciba-Geigy. In 1997 he became head of Stability Kinetics group at Novartis, joining Solvias two years later where he is currently head of the department Solid-State Development. Dr. Hilfiker has taught physical chemistry in New York and Basel, and is a recipient of the Jacottet-Kng Award and a Treubel Fellowship. He is author of more than 50 scientific publications in various areas of physical chemistry.
Inhaltsangabe
Relevance of Solid-state Properties for Pharmaceutical Products Thermodynamics of Polymorphs Characterization of Polymorphic Systems using Thermal Analysis Solid-state NMR Spectroscopy Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization Crystallography for Polymorphs Light Microscopy The Importance Solvates Physical Characterization of Hygroscopicity in Pharmaceutical Solids The Amorphous State Approaches to Polymorphism Screening Salt Selection Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality Polymorphism and Patents from A Chemist's Point of View Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications
Relevance of Solid-state Properties for Pharmaceutical Products Thermodynamics of Polymorphs Characterization of Polymorphic Systems using Thermal Analysis Solid-state NMR Spectroscopy Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization Crystallography for Polymorphs Light Microscopy The Importance Solvates Physical Characterization of Hygroscopicity in Pharmaceutical Solids The Amorphous State Approaches to Polymorphism Screening Salt Selection Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality Polymorphism and Patents from A Chemist's Point of View Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications
Rezensionen
"...ist dem Buch ein großer Leserkreis zu wünschen, und vor allem für Studierende wird die Lektüre ein großer Gewinn sein, da in den meisten Grundvorlesungen der Chemie das Thema Polymorphie ausgelassen wird. Darüber hinaus ist es Wissenschaftlern in der pharmazeutischen Industrie und an Hochschulen, die sich für die Charakterisierung organischer Festkörper interessieren, sehr zu empfehlen." (Angewandte Chemie)
"...the book should be warmly welcomed and widely read. I shall frequently want to refer to it myself, and it will be particularly valuable to students learning about the subject. The latter advantage is especially important, given that most undergraduate courses in chemistry seem to ignore polymorphism, in spite of the fact that it is a ubiquitous phenomenon and is of critical industrial importance. The text of the book is generally clearly written and the illustrations are very helpful. The index is useful and the table of contents is very clearly set out. I recommend the book to a wide range of readership in the pharmaceutical industry and in academia - indeed, to all chemists interested in the characterization of solid organic compounds." Angewandte Chemie"...ist dem Buch ein großer Leserkreis zu wünschen, und vor allem für Studierende wird die Lektüre ein großer Gewinn sein, da in den meisten Grundvorlesungen der Chemie das Thema Polymorphie ausgelassen wird. Darüber hinaus ist es Wissenschaftlern in der pharmazeutischen Industrie und an Hochschulen, die sich für die Charakterisierung organischer Festkörper interessieren, sehr zu empfehlen." (Angewandte Chemie)
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