Upendra Bhele

Insilico Binding Studies of Phenolic Compounds With Tyrosinase

Vitiligo Is an Acquired Cutaneous Skin Disease Characterized By Declining Melanocyte Function and Depigmentation

• Broschiertes Buch

Produktbeschreibung

Copper containing tyrosinase enzyme is responsible for melanin biosynthesis in human. Anomalous growth of this enzyme causes hyper-pigmentation related disorders. Monophenols and Diphenols compounds are used as inhibitors and among these the some compounds exhibited significant inhibitory activities against the tyrosinase. Molecular docking studies of these enzymes with those metabolites have been the focus of this study. The active site of the tyrosinase is the two copper ions as binding site. The metal ions seem to play an important role in establishing the interaction within the cavity of active sites. Discovery Studio3.1 was utilized to investigate the conformation and binding affinities of our small molecules. The results indicate a possible mechanism for their anti-tyrosinase activity which may involve anability to chelate the copper atoms which are required for the catalytic activity of tyrosinase.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 96
• Erscheinungstermin: 20. Dezember 2013
• Englisch
• Abmessung: 220mm x 150mm x 6mm
• Gewicht: 161g
• ISBN-13: 9783659463747
• ISBN-10: 3659463744
• Artikelnr.: 40161123

Autorenporträt

As a Bioinformatics postgraduate (MSc, MTech) Upendra Bhele has worked on various projects as chemoinformatics, pharmacoinformatics and docking studies. He has various research papers under his name