Telomerase Inhibition - Andrews, Lucy / Tollefsbol, Trygve O. (eds.)
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Due in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade. The recent advances in methods of telomerase inhibition encompass many different areas of research including molecular biology, cell biology, biochemistry, oncology and gerontology. Telomerase Inhibition provides methods and protocols for those researchers. The techniques described in this book should provide the researcher with a diverse and comprehensive set of tools with which to study telomerase inhibition. Leaders in the field provide recently…mehr

Produktbeschreibung
Due in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade. The recent advances in methods of telomerase inhibition encompass many different areas of research including molecular biology, cell biology, biochemistry, oncology and gerontology. Telomerase Inhibition provides methods and protocols for those researchers. The techniques described in this book should provide the researcher with a diverse and comprehensive set of tools with which to study telomerase inhibition. Leaders in the field provide recently developed methods that have widespread application such as targeting the telomerase holoenzyme, its RNA template and other elements associated with telomerase activity. Additional methods involving the screening of telomerase inhibitors and telomerase inhibition combined with other chemotherapeutic agents are presented. This text, on the cutting edge of the field, will provide investigators with the most recent methods applied to the expanding field of telomerase inhibition.
  • Produktdetails
  • Methods in Molecular Biology Vol.405
  • Verlag: Springer, Berlin
  • Artikelnr. des Verlages: 12007288
  • Erscheinungstermin: Dezember 2007
  • Englisch
  • Abmessung: 241mm x 160mm x 16mm
  • Gewicht: 477g
  • ISBN-13: 9781588296832
  • ISBN-10: 1588296830
  • Artikelnr.: 22735766
Autorenporträt
Lucy Andrews, University of Alabama at Birmingham, AL, USA / Trygve O. Tollefsbol, University of Alabama at Birmingham, Birmingham, AL, USA
Inhaltsangabe
Contents:

Preface
Contributors

1. Methods of Telomerase Inhibition
Lucy G. Andrews and Trygve O. Tollefsbol

2. Telomerase Inhibition by Synthetic Nucleic Acids and
Chemosensitization in Human Bladder Cancer Cell Lines
Kai Kraemer, Susanne Fuessel, and Axel Meye

3. hTERT Knockdown in Human Embryonic Kidney Cells Using
Double-Stranded RNA
Serene R. Lai, Lucy G. Andrews, and Trygve O. Tollefsbol

4. RNA Interference Using a Plasmid Construct Expressing Short Hairpin
RNA
Serene R. Lai, Lucy G. Andrews, and Trygve O. Tollefsbol

5. Retrovirus-mediated RNA Interference: Targeting hTERT Through Stable
Expression of Short Hairpin RNA
Amanda P. Cunningham, Lucy G. Andrews, and Trygve O. Tollefsbol

6. Telomerase Inhibition and Telomere Targeting in Hematopoietic Cell
Lines with Small Non-Nucleosidic Synthetic Compounds (BIBR1532)
Hesham El Daly and Uwe M. Martens

7. Uses of Telomerase Peptides in Anti-tumor Immune Therapy
He Li, Indzi Katik, and Jun-Ping Liu

8. Establishing Cell-based Reporter Systems for the Analysis of hTERT
expression
Yi-Yuan Huang, Jing-Wen Shih, and Jing-Jer Lin

9. Telomerase RNA Inhibition Using Antisense Oligonucleotide Against
Human Telomerase RNA Linked to a 2', 5'-Oligoadenylate (2-5A)
Yasuko Kondo and Seji Kondo

10. Knockdown of Telomerase RNA Using Hammerhead Ribozymes and RNA
Interference
Shang Li, Mehdi Nosrati, and Mohammed Kashani-Sabet

11. Evaluation of Tankyrase Inhibition in Whole Cells
Tomohazu Ohishi, Takashi Tsuruo, and Hiroyuki Seimiya

12. Inhibition of Telomerase by Targeting MAP Kinase Signaling
Dakang Xu, He Li, and Jun-Ping Li

13. Screening of Telomerase Inhibitors
Elke Kleideiter, Kamilla Piotrowska, and Ulrich Klotz

14. Telomerase Inhibition Combined with Other Chemotherapeutic Reagents
to Enhance Anti-Cancer Effect
Tetsuzo Tauchi, Junko H. Ohyashiki,and Kazuma Ohyashiki
Rezensionen
From the reviews:

"This book contains 14 chapters by active players in the telomerase field. ... Overall this book will be a useful resource for researchers performing telomerase-related experiments." (Lionel Guittat and Jean-Louis Mergny, ChemMedChem, Issue 3, 2008)