Cellular and Molecular Toxicology of Nanoparticles
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This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and…mehr

Produktbeschreibung
This edited book is a compilation of findings on the molecular and cellular toxicity of nanoparticles (NPs) in animal cell, human cells, invertebrates. The varied selection of test models will provide better understanding about the horizon of NPs toxicity. Interaction of NPs with cells and its organelles can induce toxicological consequences, including transcriptional and translational alterations, DNA damage, cytotoxicity, oxidative stress, mitochondrial dysfunction and cell death. NPs can get internalized in cells through phagocytosis, macropinocytosis, receptor-mediated endocytosis and passive penetration, which can affect varied cell types. Readers will be benefited with the compilations on basic and molecular facet of NPs toxicity. The chapters will provide a comprehensive information on the state-of-the-art methodologies. The application of toxicogenomic approaches, which is already established in nanotoxicology, has been given special consideration to unravel the toxicodynamics of nanomaterials. Among these approaches, the high-throughput RNA sequencing (RNA-Seq), which is able to build a complete map of transcriptome across different cell types and perturbations upon NPs exposure has been included. The readers are also introduced to the less studied topic on the adsorption of biomolecules (mainly proteins) on the NPs surface, constituting the so-called "biomolecular corona". The book has been designed for scientists engaged in NPs toxicity research. Nonetheless, it should be of interest to a variety of scientific disciplines including marine biology, environmental pollution, genetics, pharmacology, medicine, drug and food material sciences, consumer products. Also, the compilations will be of interest to the environmental watchdogs, federal regulators, risk assessors and the policy makers.
  • Produktdetails
  • Advances in Experimental Medicine and Biology .1048
  • Verlag: Springer, Berlin; Springer International Publishing
  • Artikelnr. des Verlages: 978-3-319-72040-1
  • 1st ed. 2018
  • Erscheinungstermin: 2. März 2018
  • Englisch
  • Abmessung: 261mm x 184mm x 25mm
  • Gewicht: 920g
  • ISBN-13: 9783319720401
  • ISBN-10: 3319720406
  • Artikelnr.: 49622518
Autorenporträt
Dr. Quaiser Saquib is currently working as an Assistant Professor in Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia. He is also serving as coordinator of Al-Jeraisy Chair for DNA Research in KSU. He earned his PhD from AMU, India. Much of his experience has been doing the molecular toxicity and biophysical research. Dr. Saquib has been conferred "Scientist of the Year Award-2016" by National Environmental Science Academy, India and "Young Scientist Award 2008" by Environmental Mutagen Society of India. There are 46 research publications, 2 books and 2 book chapters has been added to his credentials. He is principal and co-investigator in several projects funded by National Plan for Science and Technology, Saudi Arabia. Dr. Saquib is also engaged in teaching and training of graduate and postgraduate students at KSU.
Inhaltsangabe
Toxicity Assessment in The Nanoparticle Era .................... Valeria De Matteis, Rosaria Rinaldi Chapter 2 Mechanisms of Uptake and Translocation of Nanomaterials in the Lung ................................................................................ Chloé Puisney, Armelle Baeza-Squiban, Sonja Boland Chapter 3 Transmucosal Nanoparticles: Toxicological Overview .......................... Swapnil Talkar, Sagar Dhoble, Anuradha Majumdar, Vandana Patravale Chapter 4 The Toxicity of Nanoparticles to Human Endothelial Cells ........... Yi Cao Chapter 5 The Role of Autophagy in Nanoparticles-Induced Toxicity and its Related Cellular and Molecular Mechanisms ...................... Yubin Li, Dianwen Ju Chapter 6 Nanoparticles-Caused Oxidative Imbalance ............................... Mariusz Zuberek, Agnieszka Grzelak Chapter 7 Toxicity of Metal Oxide Nanoparticles .............................. Koyeli Girigoswami Chapter 8 Relevance of Physicochemical Characterization of Nanomaterials for Understanding Nano-Cellular Interactions .......................... Henriqueta Louro Chapter 9 Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation .............. Sourabh Dwivedi, Quaiser Saquib, Bilal Ahmad, Ameer Azam, Javed Musarrat Chapter 10 Nickel Oxide Nanoparticles Induced Transcriptomic Alterations in HepG2 Cells ......................................................................... Quaiser Saquib, Maqsood A Siddiqui, Javed Ahmad, Sabiha M. Ansari, Mohammad Faisal, Abdulrahman A. Alatar, Abdulaziz A. Al-Khedhairy Chapter 11 Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona ................................................. Saad Mohammad Ahsan, Chintalagiri Mohan Rao, Md. Faiz Ahmad Chapter 12 Cellular and Molecular Toxicity of Iron Oxide Nanoparticles ................. Blanca Laffon, Natalia Fernández-Bertólez, Carla Costa, Fátima Brandão, João Paulo Teixeira, Eduardo Pásaro, Vanessa Valdiglesias Chapter 13 Detection of DNA Damage Induced by Cerium Dioxide Nanoparticles: From Models to Molecular Mechanism Activated ........................ Tiago Alves Jorge de Souza, Thiago Lopes Rocha, Leonardo Pereira Franchi Chapter 14 Mechanisms Underlying Neurotoxicity of Silver Nanoparticles ................. Lidia Struzynska, Joanna Skalska Chapter 15 Toxic and Beneficial Potential of Silver Nanoparticles: The Two Sides of the Same Coin ........................... Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza Chapter 16 Molecular and Cellular Toxicology of Nanomaterials with Related to Aquatic Organisms ..................................... Mohd Ashraf Rather, Irfan Ahmad Bhat, Niti Sharma, Rupam Sharma Chapter 17 Cytotoxicity and Physiological Effects of Silver Nanoparticles on Marine Invertebrates ........................................................ Adriano Magesky and Émilien Pelletier Chapter 18 A Drosophila Model to Decipher the Toxicity of Nanoparticles Taken Through Oral Routes ...................................... S. Aurosman Pappus, Monalisa Mishra Chapter 19 Using of Quantum Dots in Biology and Medicine ........................... Svetlana Pleskova, Elza Mikheeva, Ekaterina Gornostaeva