The actin cytoskeleton plays a central role in many cellular processes including cell motility, cytokinesis, endocytosis and phagocytosis. The structure and dynamics of the actin cytoskeleton is regulated by a large number of proteins that interact with monomeric and/or filamentous actin. Actin monomer binding proteins provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin. TOC:How Actin Assembly Is Modulated at Filament Barbed Ends in Motile Processes.-Proteins of the Actin Depolymerizing Factor/Cofilin Family.- Profilin, an Essential Control Element for Actin Polymerization.- Srv2/Cyclase-Associated Protein (CAP): A Multi-Functional Recycling Center for Actin Monomers and Cofilin.- Twinfilin Family of Actin Monomer-Binding Proteins.- Intracellular ß-Thymosins.- Multirepeat ß-Thymosins.- Wasp and WAVE Family Proteins.- The Verprolins as Regulators of Actin Dynamics.- A Common Binding Site for Actin-Binding Proteins on the Actin Surface.
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