Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility. There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders. TOC:Overview of actin.- Actin Genetic Diseases.- Actin-binding drugs.- Filamentous actin as an autoantigen.- Actin Binding Protein Function and its Relation to Disease Pathology.- ADF/cofilin, actin dynamics and disease.- Gelsolin and disease.- Profilin and disease.- The roles of thymosin beta4 in cell migration and cell-to-cell signalling in disease.- Actin and actin binding proteins in cancer progression and metastasis.- Defects in actin and actin-binding proteins in leukocytes.- The role of PIP2 in actin, actin-binding proteins and disease.- Intracellular pathogens and the actin cytoskeleton.- Actin and its binding proteins in heart failure.
Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.