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Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy of all viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets for the development of antiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of…mehr

Produktbeschreibung
Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy of all viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets for the development of antiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of antiviral agents. By combining studies of both RNA and DNA viruses - and more - into a single volume, the editors have created a mechanism for cross-talk between the fields that will produce synergy and could lead to more rapid discovery of approaches to treat viral infections.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 28.05.2009
  • Englisch
  • ISBN-13: 9780387894560
  • Artikelnr.: 37289021
Inhaltsangabe
Genome replication strategies.- Model of Picornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C Virus Genome Replication.- Brome Mosaic Virus RNA Replication and Transcription.- Retroviruses.- Hepadnaviral Genomic Replication.- Rhabdoviruses.- Orthomyxovirus Genome Transcription and Replication.- Arenaviruses: Genome Replication Strategies.- Core-Associated Genome Replication Mechanisms of dsRNA Viruses.- Poxviruses.- Herpesvirus Genome Replication.- Host Factors Promoting Viral RNA Replication.- Host Factors that Restrict Retrovirus Replication.- Elements, factors and enzymes: Structure-function and mechanism.- T4 Phage Replisome.- Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase.- RNA Virus Polymerases.- Human Immunodeficiency Virus Reverse Transcriptase.- Viral Helicases.- Integrase: Structure, Function, and Mechanism.- Antivirals: Targets, mechanisms and resistance.- Viral DNA Polymerase Inhibitors.- Viral RNA Polymerase Inhibitors.- HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance.- Lethal Mutagenesis.- Clinical Implications of Reverse Transcriptase Inhibitor Resistance.
Rezensionen
From the reviews: "Viruses are primarily classified by the structure of their genomes. ... they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ... the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ... I recommend this title to all those interested in viral replication." (Christopher Ring, Microbiology Today, November, 2009)