Oral Precancer (eBook, ePUB)

Diagnosis and Management of Potentially Malignant Disorders
Redaktion: Thomson, Peter

• Format: ePub

Produktbeschreibung

Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oral cancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development. Written and edited by prominent researchers in the field, Oral Precancer: * Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases * Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity * Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma * Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and more From start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 240
• Erscheinungstermin: 30. Januar 2012
• Englisch
• ISBN-13: 9781118346433
• Artikelnr.: 37357678

Autorenporträt

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

Inhaltsangabe

List of Contributors Preface Acknowledgements 1. Introduction General
Introduction Epidemiology Prevention Treatment Strategies Terminology
Summary References 2. Structure and Function of Oral Mucosa Introduction
Applied Anatomy of the Oral Cavity Function of the Oral Mucosa The
Microanatomy of Oral Mucosa Regional Variation of Oral Mucosa Oral
Epithelial Cell Kinetics Oral Epithelial Cell Proliferative Activity
Anatomical Site Predilection for Oral Carcinogenesis Summary References 3.
Oral Carcinogenesis Introduction Oral Cancer and Precancer The 'Progression
Model' for Oral Cancer Aetiology and Risk Factors Patient and Risk Factor
Profiling Summary References 4. Clinical Presentation of Oral Precancer
Introduction Clinical Terminology Precancerous (Premalignant) Lesions
Precancerous (Premalignant) Conditions Multiple Lesion Disease Summary
References 5. Diagnostic Methods Introduction Screening Clinical
Examination Techniques Vital Tissue Staining Light Based Detection Systems
Brush Biopsy and Exfoliative Cytology Clinical Diagnosis in Practice
Summary References 6. Pathological Aspects of Oral Precancer Introduction
Biopsy Techniques The Role of the Pathologist Histopathological Features of
Oral Potentially Malignant Disorders Grading of Dysplasia Limitations in
Conventional Pathological Techniques Summary References 7. Management of
Oral Precancer Introduction Risk Factor Modification Observation versus
Intervention Medical Treatment Surgical Treatment Interventional Laser
Surgery Combined Treatment Modalities Patient Follow Up and Surveillance
Summary References 8. Clinical Outcome Introduction Clinical Outcome
Studies Patient Cohort Studies Definitions of Clinical Outcome Newcastle
Patient Cohort Studies Patient Follow Up Prediction of Clinical Outcome
Summary References 9. Malignant Transformation and Oral Cancer Development
Introduction The Risk of Progression to Oral Carcinoma Malignant
Transformation versus Oral Cancer Development Interventional Laser Surgery
and Oral Cancer Prevention The Newcastle 10 Year Follow Up Study High and
Low Risk Patients Clinical Signs of Oral Squamous Cell Carcinoma Diagnosis
and Management of 'Unexpected Malignancy' Prognosis for the 'Transformed
Patient' Summary References 10. The Future Introduction Prevention of Oral
Precancer Early Diagnosis of Potentially Malignant Disease Interventional
Management Strategies in the Future Individualised Patient Treatments -
Biomarkers and Targeted Chemoprevention Future Research Directions Summary
References 11. Case Histories Introduction Diagnosis of Unexpected
Malignancy Multiple Lesion Disease Responding to Conservative Management
Multiple Lesion Disease Requiring Repeated Laser Treatments Proliferative
Verrucous Leukoplakia Localised Oral Lichenoid Reaction Multiple Oral
Lichenoid Reactions Widespread Dysplastic Oral Lichenoid Reactions An
Immunosuppressed Patient Chronic Hyperplastic Candidosis Tobacco Associated
Hyperkeratosis Malignant Transformation in Longstanding Non-erosive Lichen
Planus Summary 12. Conclusions Oral Cancer Potentially Malignant Disorders
Clinical Management Patient Care Pathways Public Health Strategies Future
Directions Index