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Multiple sclerosis (MS) is the most common disease among thecentral nervous system (CNS) diseases, mainly affected young adults ,it's a dangerous chronic neurological disorder leads to demyelination and inflammation of white matter in the CNS.MS commonly begins between the age of 20 and 40, Men have a low risk compared to women by 3 folds. MS pathology is clinically recognized as big plaques with many focals and no mylelin sheath.Also loss of with oligodendrocyte and the axons usually are degenerated .Early phases of MS, the blood-brain barrier integrity is shown to be compromised, causing the monocytes and T cells invasions into parenchyma of the brain, therefore, the MS characteristic is the de-mylination of lesions. Environmental risk factors are of two types infectious and non-infectious factors. Non-infectious factors caused development of MS such as: low levels of vitamin D which is linked in the association between the latitude and MS risk. MS showed a complex etiology anddemonstrated a link between the genetic and environmental factors.