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  • Gebundenes Buch

Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series…mehr

Produktbeschreibung
Since the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably. Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
  • Produktdetails
  • Methods in Molecular Biology 1007
  • Verlag: Humana / Humana Press / Springer, Berlin
  • Artikelnr. des Verlages: 80031956
  • 2. Aufl.
  • Erscheinungstermin: 31. Mai 2013
  • Englisch
  • Abmessung: 260mm x 183mm x 27mm
  • Gewicht: 976g
  • ISBN-13: 9781627033916
  • ISBN-10: 1627033912
  • Artikelnr.: 37057425
Inhaltsangabe
1. Introduction to Mass Spectrometry-Based Proteomics

Rune Matthiesen and Jakob Bunkenborg

2. LC-MS Spectra Processing

Rune Matthiesen

3. Isotopic Distributions

Alan L. Rockwood and Magnus Palmblad

4. Retention Time Prediction and Protein Identification

Alex A. Henneman and Magnus Palmblad

5. Algorithms for Database Dependent Search of MSMS Data

Rune Matthiesen

6. Interpretation of Tandem Mass Spectra of Post-Translationally Modified Peptides

Jakob Bunkenborg and Rune Matthiesen

7. Improving Peptide Identification Using Empirical Scoring Systems

Robert J. Chalkley

8. Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry

Rune Matthiesen and Ana Sofia Carvalho

9. Computational Approaches to Selected Reaction Monitoring (SRM) Assay Design

Conrad Bessant and Jun Fan

10. Feature Selection and Machine Learning with Mass Spectrometry Data

Susmita Datta

11. Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data

Thomas E. Wales, Michael J. Eggertson, and John R. Engen

12. Permethylated N-Glycan Analysis with Mass Spectrometry

Zhenxin Lin and David M. Lubman

13. Mass Spectrometry Methods for Studying Glycosylation in Cancer

Hugo Osório and Celso A. Reis

14. Proteomics Data Exchange and Storage: The Need for Common Standards and Public Repositories

Rafael C. Jiménez and Juan Antonio Vizcaíno

15. Tools for Protein Post Translational Modifications Analysis: FAK, A Case Study

Catarina Fonseca, Paula Voabil, Ana Sofia Carvalho, and Rune Matthiesen

16. Proteomic Strategies to Characterize Signaling Pathways

H.C. Harsha, Sneha M. Pinto, and Akhilesh Pandey

17. Simple Proteomics Data Analysis in the Object-Oriented PowerShell

Yassene Mohammed and Magnus Palmblad