Toshimitsu Niwa

Uremic Toxins (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: * Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins * Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs * Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 400
• Erscheinungstermin: 4. September 2012
• Englisch
• ISBN-13: 9781118424100
• Artikelnr.: 37349620

Autorenporträt

TOSHIMITSU NIWA, MD, PhD, is Professor in the Department of Advanced Medicine for Uremia at the Nagoya University Graduate School of Medicine. President of the Japanese Society for Biomedical Mass Spectrometry, Dr. Niwa has received many honors for his research, including the Kimoto Prize of the Japanese Society for Dialysis Therapy and the International Society of Uremia Research and Toxicity Award. He has published more than 300 articles in peer-reviewed journals.

Inhaltsangabe

PREFACE ix CONTRIBUTORS xi SECTION 1: UREMIC TOXINS 1 1. Uremic Toxins: An
Integrated Overview of Definition and Classification 3 Richard J. Glassock
and Shaul G. Massry 2. Classification and a List of Uremic Toxins 13
Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond Vanholder, and Griet
Glorieux 3. Analysis of Uremic Toxins with Mass Spectrometry 35 Toshimitsu
Niwa SECTION 2: SELECTED UREMIC TOXINS 51 4. Indoxyl Sulfate 53 Toshimitsu
Niwa 5. p-Cresyl Sulfate 77 Anneleen Pletinck, Raymond Vanholder, and Griet
Glorieux 6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid 87 Toshimitsu
Niwa 7. Phenylacetic Acid 99 Anna Schulz and Joachim Jankowski 8.
Homocysteine and Hydrogen Sulfide, Two Opposing Aspects in the Pathobiology
of Sulfur Compounds in Chronic Renal Failure 109 Alessandra F. Perna and
Diego Ingrosso 9. Guanidino Compounds 125 Sunny Eloot, Griet Glorieux,
Peter Paul De Deyn, and Raymond Vanholder 10. Asymmetric Dimethylarginine
143 Vladim?r Teplan and Jaroslav Racek 11. Nicotinamide Metabolites 163
Boleslaw Rutkowski and Przemyslaw Rutkowski 12. Dicarbonyls (Glyoxal,
Methylglyoxal, and 3-Deoxyglucosone) 177 Naila Rabbani and Paul J.
Thornalley 13. Glucose Degradation Products in Peritoneal Dialysis 193
Monika Pischetsrieder and Sabrina Gensberger 14. Dinucleoside
Polyphosphates 209 Joachim Jankowski and Vera Jankowski 15. Parathyroid
Hormone 227 Shaul G. Massry and Miroslaw Smogorzewski 16. b2-Microglobulin
249 Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei
Narita, and Fumitake Gejyo 17. Cytokines 259 BjEURorn Anderstam, Bengt
Lindholm, and Peter Stenvinkel 18. Free Immunoglobulin Light Chains 279
Gerald Cohen and Walter H. HEURorl 19. Advanced Glycation Endproducts
(AGEs) 293 Naila Rabbani and Paul J. Thornalley 20. Oxidized Albumin 305
Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian Marco
Ghiggeri SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS 315 21.
Therapeutic Removal of Uremic Toxins by Hemodialysis 317 Tammy L. Sirich,
Pavel Aronov, and Timothy W. Meyer 22. Therapeutic Removal of Uremic Toxins
by Peritoneal Dialysis 331 Malgorzata Debowska, Elvia Garc?a-Lopez, Jacek
Waniewski, and Bengt Lindholm 23. Therapeutic Removal of Uremic Toxins by
Oral Sorbent 359 Toshimitsu Niwa INDEX 373