LC-MS in Drug Bioanalysis

Herausgegeben:Madden L., Timothy; Xu, Quanyun A.

• Gebundenes Buch

Produktbeschreibung

Clinical pharmacology plays an important role in today's medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography - mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.

Produktdetails

• Verlag: Springer / Springer US / Springer, Berlin
• Artikelnr. des Verlages: 80016224, 978-1-4614-3827-4
• 2012
• Seitenzahl: 484
• Erscheinungstermin: 16. Juli 2012
• Englisch
• Abmessung: 241mm x 160mm x 29mm
• Gewicht: 860g
• ISBN-13: 9781461438274
• ISBN-10: 1461438276
• Artikelnr.: 35105795

Inhaltsangabe

Internal standards for quantitative LC-MS bioanalysis.- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS.- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry.- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry.- Pitfalls of LC-MS/MS in the clinical laboratory.- Therapeutic drug monitoring to support clinical pharmacogenomics.- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices.- The analysis of antipsychotic drugs in human biosamples by LC-MS.- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective.- Applications of mass spectrometry in analyses of steroid hormones.- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications.- Analysis of illicit drugs in human biological samples by LC-MSn.- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs.- A planar integrated micro mass spectrometer.