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Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume's companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.…mehr

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Produktbeschreibung
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume's companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GB, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 01.01.2010
  • Englisch
  • ISBN-13: 9781597452922
  • Artikelnr.: 37341016
Autorenporträt
Sonia Jakowlew, National Cancer Institute, Rockville, MD, USA
Inhaltsangabe
Transforming Growth Factor-ß in Cancer Therapy
Volume 1: Basic and Clinical Biology
Sonia B. Jakowlew, Ph.D., Editor
The Humana Press, Inc., Publisher
TABLE OF CONTENTS
In Memorium for Anita B. Roberts, PhD
John M. McPherson
Preface
Sonia B. Jakowlew
Foreward
Michael B. Sporn
Contributors
Part I. Basic Concepts of TGF-ß Signaling in Normal Physiology and
Cancer Pathobiology
1 Component Hardware for Transforming Growth Factor-ß Signal
Transduction: TGF-ß Ligands, TGF-ß Receptors, and Smads
Sonia B. Jakowlew
2 TGF-ß Signaling in Homeostasis and Cancer
Joan Seoane
3 TGF-ß Availability: Latent TGF-ß and Latent TGF-ß Binding Proteins
Vesna Todorovic and Daniel B. Rifkin
4 Biological Functions of Latent TGF-ß Binding Proteins and
Activation of TGF-ß Marko Hyytiäanen , Katri Koli, and Jorma Keski-Oja
5 Regulators of Smad2/3 Transcription and Phosphorylation
Azeddine Atfi and Marie-Francoise Bourgeade
6 Interaction of Smad4 and Embryonic Liver Fodrin (ELF)-ß-spectrin in
Hyperplasia,Neoplasia, and
Tumor Progression
Sang Soo Kim, Charles Shuman, and Lopa Mishra
7 Regulation of Smad Activity by Phosphorylation
Fang Liu
8 Nuclear Targeting of TGF-ß-activated Smads in Normal and Tumor Biology
Lan Xu
9 Ski, Sno and Akt as Negative Regulators of Smad Activity: Balancing
Cell Death and Cell Survival
Erwan Le Scolan and Kunxin Luo
10 Smurfs in TGF-ß Signaling and Regulation of Bone Homeostasis and
Cancer
Ying E. Zhang and Motozo Yamashita
11 Involvement of KM23 Dynein Light Chains in TGF-ß Signaling
Qunyan Jin, Guofeng Gao, and Kathleen M. Mulder
12 TGF-ß Signaling in Fibroblastic Cells and Oncogenes
Neil A. Bhowmick
13 Mechanisms of TGF-ß-induced Apoptosis in Cancer Cells
Tae-Aug Kim and Seong-Jin Kim
14 Mechanisms of Cell CycleRegulation by TGF-ß Disabled in Cancer
Leslie I. Gold and Jon Lecanda
15 Proteasome in the Control of TGF-ß Signaling During Development and
Cancer
Arja Band and Marikki Laiho
16 TGF-ß and Smad Signaling in Transcriptome ReprogrammingDuring
Epithelial to Mesenchymal
Transition
Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, and Aristidis
Moustakas
17 Functional Interaction between MMPs and TGF-ß in Normal and Tumor
Tissue
Christina H. Stuelten , Anita B. Roberts, and William G.
Stetler-Stevenson
18 Cooperation Between TGF-ß and Wnt Pathway Components in Regulating
Mesenchymal Stem Cell
Function
Irwin M. Liu, Steven H. Schilling, and Xiao-Fan Wang
19 Interaction of Oncogenic Ras and TGF-ß1 Signaling in Cancer: Lessons
from the Multistage Skin
Carcinogenesis Model
Adam Glick , Dong-Soon Bae, Xin Liu, and Kinnimulki Vijayachandra
Part II. TGF-ß Superfamily Members in Normal and Tumor Biology
20 Proteomics Analysis of TGFß Superfamily Members
Serhiy Souchelnytskyi
21 Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally
Occurring Therapeutic Agent for Certain
Human Cancers
David T. MacLaughlin and Patricia K. Donahoe
22 Activins, Inhibins and Bone Morphogenetic Proteins as Modulators of
Prostate Cancer Progression
Tetsu Hayashida, Vandana Gupta, Sam Thiagalinam, and Shyamala
Maheswaran
23 Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
George Berberian, Deepak Malhotra, and John E. Langenfeld
24 Histone Methyltransferase and Smad Interactions in BMP Signaling
Jennifer E. Leader, M. Pilar Frontelo, and Robert J. Lechleider
25 Endoglin (CD105): A Strong Candidate for Immunologic Targeting of
Tumor Neovasculature in Human
Malignancies
Ester Fonsatti and Michelle Maio
26 Activins and Inhibins in Cancer Progression
Gail P. Risbridger and
Rezensionen
From the reviews: "This volume provides a comprehensive review of TGF-beta regulation, signaling, and cellular function in both normal and tumor biology. ... will be of use to individuals interested in the role of TGF-beta in the development of cancer and fibrosis. This will likely benefit readers interested in TGF-beta in the pathogenesis of disease ... . also be a resource for those interested in the complex intracellular signaling cascades elicited by TGF-beta in normal and altered cells." (James P Luyendyk, Doody's Review Service, May, 2008)