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The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This…mehr

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Produktbeschreibung
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book. TOC:Foreword.- Inflammation and Cancer: The role of the immune response and angiogenesis.- Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers.- Cytokines, NF-kB, Microenvironment, Intestinal Inflammation and Cancer.- Regulation of NF-kB Transcriptional Activity.- The Role of Immune Cells in the Tumor Microenvironment.- Tumor-Microenvironment Interactions: The Selectin-Selectin Ligand Axis in Tumor-Endothelium Cross Talk.- CD95L/FasL and Trail in Tumour Surveillance and Cancer Therapy.- Infection & Neoplastic Growth 101: The required reading for microbial pathogens aspiring to cause cancer.- Cytokines as Mediators and Targets for Cancer Cachexia.- Targeting NF-kB in Anticancer Adjunctive Chemotherapy.- Index.

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  • Produktdetails
  • Verlag: Springer-Verlag GmbH
  • Erscheinungstermin: 05.03.2006
  • Englisch
  • ISBN-13: 9780387262833
  • Artikelnr.: 37286743
Autorenporträt
Angus Dalgleish, Saint George's Hospital Medical School, London, UK / Burkhard Haefner, Johnson & Johnson Pharmaceutical Research & Development, Beerse, Belgium
Inhaltsangabe
Foreword.- Inflammation and Cancer: The role of the immune response and angiogenesis.- Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers.- Cytokines, NF-kB, Microenvironment, Intestinal Inflammation and Cancer.- Regulation of NF-kB Transcriptional Activity.- The Role of Immune Cells in the Tumor Microenvironment.- Tumor-Microenvironment Interactions: The Selectin-Selectin Ligand Axis in Tumor-Endothelium Cross Talk.- CD95L/FasL and Trail in Tumour Surveillance and Cancer Therapy.- Infection & Neoplastic Growth 101: The required reading for microbial pathogens aspiring to cause cancer.- Cytokines as Mediators and Targets for Cancer Cachexia.- Targeting NF-kB in Anticancer Adjunctive Chemotherapy.- Index.