Cancer Gene Therapy by Viral and Non-Viral Vectors

Herausgegeben von Brenner, Malcolm; Hung, Mien-Chie

• Gebundenes Buch

Produktbeschreibung

Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy

Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor.
This book provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains how these are being used for gene-based cancer therapies. Designed as a volume in the Translational Oncology book series, Cancer Gene Therapy by Viral and Non-viral Vectors deals with the practice of gene-therapy, with reference to vectors for gene expression and gene transfer, as well as viral therapy. It covers the history and current and future applications of gene transfer in cancer, and provides expert insight on the progress of viral and non-viral gene therapy with regard to delivery system, vector design, potential therapeutic genes, and principles and regulations for cancer gene therapy.
Presented in three parts, Cancer Gene Therapy by Viral and Non-viral Vectors covers:

Delivery Systems

Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors

Retroviruses for Cancer Therapy

DNA Plasmids for Non-viral Gene Therapy of Cancer

Cancer Therapy with RNAi delivered by Non-viral Membrane/Core Nanoparticles

Targeted Expression

Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promptors

MicroRNAs as Drugs and Drug Targets in Cancer

Principles of Clinical Trials in Gene Therapy

Regulatory issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials

US Regulations Governing Clinical Trials in Gene Therapy

Remaining Obstacles to the Success of Cancer Gene Therapy

Focusing on speeding the process in clinical cancer care by bringing therapies as quickly as possible from bench to bedside, Cancer Gene Therapy by Viral and Non-viral Vectors is an absolutely vital book for physicians, clinicians, researchers, and students involved in this area of medicine.

Produktdetails

• Translational Oncology
• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 176
• Erscheinungstermin: 17. März 2014
• Englisch
• Abmessung: 257mm x 183mm x 15mm
• Gewicht: 590g
• ISBN-13: 9781118501627
• ISBN-10: 1118501624
• Artikelnr.: 40557428

Autorenporträt

Edited by Malcolm K. Brenner, MB, BChir, PhD, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA Mien-Chie Hung PhD, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Inhaltsangabe

List of Contributors
vii Series Foreword
ix Preface
xi Part I Delivery Systems 1 Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors
3 Vincenzo Cerullo
Kilian Guse
Markus Vähä-Koskela
and Akseli Hemminki 2 Retroviruses for Cancer Therapy
21 Jiehua Zhou
Yue Ding
John C. Burnett
and John Rossi 3 DNA Plasmids for Non-viral Gene Therapy of Cancer
39 Amer M. Najjar
Judy S.E. Moyes
and Laurence J.N. Cooper 4 Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core Nanoparticles
61 Andrew B. Satterlee and Leaf Huang Part II Targeted Expression 5 Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters
81 Jennifer L. Hsu
Longfei Huo
Chia-Wei Li
Yi-Hsin Hsu
Yan Wang
and Mien-Chie Hung 6 MicroRNAs as Drugs and Drug Targets in Cancer
97 Hui Ling and George A. Calin Part III Principles of Clinical Trials in Gene Therapy 7 Regulatory Issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/II Trials
115 Adrian P. Gee and Zhuyong Mei 8 US Regulations Governing Clinical Trials in Gene Therapy
131 Bambi Grilley 9 Remaining Obstacles to the Success of Cancer Gene Therapy
151 Malcolm K. Brenner Index
157