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This volume provides readers with a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians. This book has 14 chapters that will describe (1) the metabolism in brain of glycerophospholipids, including those containing a vinyl ether group (plasmalogens); (2) cutting edge information on the properties and roles of phospholipases…mehr

Produktbeschreibung
This volume provides readers with a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians. This book has 14 chapters that will describe (1) the metabolism in brain of glycerophospholipids, including those containing a vinyl ether group (plasmalogens); (2) cutting edge information on the properties and roles of phospholipases A2 in the central nervous system; (3) the release by phospholipases A2 of second messengers (arachidonic acid, docosahexaenoic acid, and lysophospholipid) from neural membrane phospholipids and their neurochemical effects on brain metabolism and functions; (4) the involvement of phospholipases A2 in neurological and neuropsychiatric disorders, and the use of phospholipase A2 inhibitors for the treatment of diseases associated with altered phospholipid metabolism; and (5) methods for the assays of phospholipases A2 and their clinical significance.
  • Produktdetails
  • Verlag: Springer New York / Springer US
  • Artikelnr. des Verlages: 11691075
  • 2007
  • Seitenzahl: 416
  • Erscheinungstermin: 18. Oktober 2006
  • Englisch
  • Abmessung: 235mm x 155mm x 31mm
  • Gewicht: 863g
  • ISBN-13: 9780387366029
  • ISBN-10: 0387366024
  • Artikelnr.: 20922570
Autorenporträt
L.A. Horrocks, Ohio State University, Columbus, Ohio, USA
Inhaltsangabe
Phospholipid Metabolism in Brain.
Ether Lipids in Brain.
Phospholipases A2 in Brain.
Roles of Phospholipases A2 in Brain.
Arachidonic Acid and Its Metabolites in Brain.
Docosahexaenoic Acid and Its Metabolites in Brain.
Nonenzymic Metabolites of Arachidonate and Docosahexaenoate in Brain.
Lyso
Glycerophospholipids.
Lysophosphatidic Acid and Its Metabolism in Brain.
Involvement of Phospholipids and Phospholipases A2.
Inhibitors of Phospholipases A2 and Their Use for the Treatment of Neurological Disorders.
Assay Methods for Phospholipase A2 Activities in Brain.
Glycerophospholipids and Phospholipases A2 in Neuropsychiatric Disorders.
Future Perspectives: Metabolic and Functional Aspects of Neural Membrane Glycerophospholipids.

Phospholipid Metabolism in Brain.- Ether Lipids in Brain.- Phospholipases A2 in Brain.- Roles of Phospholipases A2 in Brain.- Arachidonic Acid and Its Metabolites in Brain.- Docosahexaenoic Acid and Its Metabolites in Brain.- Nonenzymic Metabolites of Arachidonate and Docosahexaenoate in Brain.- Lyso-Glycerophospholipids.- Lysophosphatidic Acid and Its Metabolism in Brain.- Involvement of Phospholipids and Phospholipases A2.- Inhibitors of Phospholipases A2 and Their Use for the Treatment of Neurological Disorders.- Assay Methods for Phospholipase A2 Activities in Brain.- Glycerophospholipids and Phospholipases A2 in Neuropsychiatric Disorders.- Future Perspectives: Metabolic and Functional Aspects of Neural Membrane Glycerophospholipids.