Neural Transplantation in Neurodegenerative Disease (eBook, PDF)

Current Status and New Directions
Redaktion: Chadwick, Derek J.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

The field of neural transplantation is at a crucial stage in its development, with results of important clinical trials on transplantation in patients with Parkinson's disease expected soon and novel, alternative approaches to fetal transplantation being actively investigated. This timely book brings together leading neuroscientists, clinicians, and cell and developmenta; biologists to discuss the use of neural transplants in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, such as xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book draws together much new and exciting work in this field, and identifies promising new research directions.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 334
• Erscheinungstermin: 9. September 2003
• Englisch
• ISBN-13: 9780470870822
• Artikelnr.: 37299980

Autorenporträt

Derek J. Chadwick and Jamie A. Goode are editors for Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions and other scientific titles.

Inhaltsangabe

Introduction (J. Gray). Cell Replacement Strategies for Neurodegenerative
Disorders (A. Björklund). Functional Analysis of Fronto-Striatal
Reconstruction by Striatal Grafts (S. Dunnett). Functional Reconstruction
of the Hippocampus: Fetal Versus Conditionally Immortal Neuroepithelial
Stem Cell Grafts (H. Hodges, et al.). Gene Transfer for Neuroprotection in
Animal Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis (M.
Bohn, et al.). Repair of Corticospinal Axons by Transplantation of
Olfactory Ensheathing Cells (G. Raisman). Neural Transplantation in
Parkinson's Disease (O. Lindvall). Transplantation of Human Fetal Striatal
Tissue in Huntington's Disease: Rationale for Clinical Studies (T. Freeman,
et al.). GENERAL DISCUSSION I: PROSPECTS FOR FETAL TRANSPLANTS.
Neurotransplantation in Neurodegenerative Disease: A Survey of Relevant
Issues in Developmental Neurobiology (J. Price, et al.). Molecular and
Cellular Mechanisms in Immune Rejection of Intracerebral Neural Transplants
(T. Brevig, et al.). Porcine Neural Xenografts: What are the Issues? (R.
Barker). Gene Transfer Techniques for the Delivery of GDNF in Parkinson's
Disease (J.-L. Ridet, et al.). Neurogenesis in the Adult Hippocampus (G.
Kempermann & F. Gage). Neural Stem Cells are Uniquely Suited for Cell
Replacement and Gene Therapy in the CNS (V. Ourednik, et al.). Functional
Repair with Neural Stem Cells (J. Sinden, et al.). Remyelinating the
Demyelinated CNS (W. Blakemore, et al.). GENERAL DISCUSSION II: THE ES CELL
APPROACH. FINAL DISCUSSION: THE FUTURE FOR FETAL GRAFTS; STEM CELL
STRATEGIES. Index of Contributors. Subject Index.