Lorenzo A. Pinna

Protein Kinase CK2 (eBook, PDF)

• Format: PDF

Produktbeschreibung

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world's leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 480
• Erscheinungstermin: 15. Oktober 2012
• Englisch
• ISBN-13: 9781118482384
• Artikelnr.: 37340564

Autorenporträt

Lorenzo A. Pinna received his B. Sc. in Biochemistry from the University of Padova in 1962. From 1965-66 he was postdoctoral fellow at the Department of Physiological Chemistry, Johns Hopkins University Medical School, Baltimore, USA. In 1975 he was appointed Professor of Medical Chemistry and Biochemistry and in 1988 Director of the Department of Biological Chemistry at the University of Padova. A pioneer in the field of CK2 research, his research interests encompass various aspects of protein phosphorylation, with special reference to the design of synthetic peptide substrates for the specific monitoring of protein kinases and the assessment of the biological role and pathogenic potential of protein kinase CK2.

Inhaltsangabe

PART I: INTRODUCTION 1. "CK2
a protein kinase for all seasons" (Lorenzo A. Pinna Dept. Biological Chemistry
University of Padua
Padua
Italy. PART II: MOLECULAR AND STRUCTURAL ASPECTS 2. "CK2 structures in the light of the spine concept of eukaryotic protein kinases " (Karsten Niefind
University of Cologne
Institute of Biochemistry
Cologne
Germany. E 3. "Structural bases for CK2 inhibition" (Roberto Battistutta
Department of Chemistry
University of Padua- Padova
Italy. 4. "The interactome of protein kinase CK2" (Mathias Montenarth
University of the Saarland
Medical Biochemistry and Molecular Biology
Homburg
Germany. 5. "The phosphoproteome generated by protein kinase CK2" (Mauro Salvi & Lorenzo A. Pinna Dept. Biological Chemistry
University of Padua
Padua
Italy. PART III: FUNCTIONAL ASPECTS 6. "Intersection of CK2 with other signalling pathways" (David Litchfield
University of Western Ontario
Department of Biochemistry
London
Ontario
Canada. 7. "The role of protein kinase CK2 in the p53 response" (David W. Meek
University of Dundee
Biomedical Research Institute Ninewells Hospital
Dundee
UK. 8. "CK2 in embryonic development" (Isabel Dominguez
Boston University School of Medicine
Boston
MA
USA. 9. "Role of CK2 in the control of epithelial cell plasticity" (Claude Cochet
INSERM U873 iRTSV- CEA Grenoble
France. 10. "CK2 and circadian rhythm" 11. "The pivotal role of CK2 in chaperoning the kinome" (Yoshihiko Miyata
Kyoto University
Dept. Cell & Develop. Biology
Kyoto
Japan. 12. "CK2: a global regulator of cell survival" (Olaf-G. Issinger
University of Southern Denmark
Institute of Biochemistry and Molecular Biology
Odense
Denmark. 13. "Specific features of plant CK2" (Montserrat Pages
CSIC
CRAG
Barcelona
Spain. PART IV: CK2 AND NEOPLASIA 14. "The oncogenic potential of CK2" (David C. Seldin
Boston University Medical Center
Department of Medicine
Boston MA
USA. 15. "CK2 suppression of apoptosis and its implication in cancer biology and therapy" (Khalil Ahmed
University of Minnesota and V.A. Medical Center
Minneapolis
MN
USA. 16. "Abnormal levels of CK2 and the generation of cancer "addiction" (Maria Ruzzene
Dept. Biological Chemistry
University of Padua
Padua
Italy. 17. "CK2 as an ideal target in cancer therapy: combining inhibitors of CK2 with various classes of chemotherapeutic agents" (Kenna Anderes
Cylene Pharmaceuticals
Cancer Biology
San Diego
CA
USA. 18. " CK2 in normal and malignant hematopoiesis" (Francesco Piazza
Venetian Institute of Molecular Medicine - VIMM
Padova
Italy.