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This introductory reference provides a practical, concise summary of everything a physician needs to know about genomics and emerging technologies. Through extensive illustrative examples, this book offers a clear and concise starting point to understanding how medicine has been, and will be, transformed by genomics and bioinformatics. Beginning with a clear overview on the Human Genome Project and its revolutionary impact, the book further investigates new technologies in detail, including: high-throughput DNA sequencing, genome sequence databases, microarrays, proteomics, pharmacogenomics, genetic testing, and gene therapy.…mehr

Produktbeschreibung
This introductory reference provides a practical, concise summary of everything a physician needs to know about genomics and emerging technologies. Through extensive illustrative examples, this book offers a clear and concise starting point to understanding how medicine has been, and will be, transformed by genomics and bioinformatics. Beginning with a clear overview on the Human Genome Project and its revolutionary impact, the book further investigates new technologies in detail, including: high-throughput DNA sequencing, genome sequence databases, microarrays, proteomics, pharmacogenomics, genetic testing, and gene therapy.

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  • Produktdetails
  • Verlag: John Wiley & Sons
  • Seitenzahl: 288
  • Erscheinungstermin: 18. Juli 2003
  • Englisch
  • ISBN-13: 9780471270614
  • Artikelnr.: 37301484
Autorenporträt
Dr. Stuart M. Brown is in the faculty of New York University School of Medicine, where he is Associate Professor and Director of the Bioinformatics Core Facility and director for the graduate course "Using Computers in Molecular Biology."
Inhaltsangabe
Preface. 1 Introduction to Molecular Genetics. The Principles of Inheritance. Genes Are Made of DNA. DNA Structure. The Central Dogma. References. 2 Molecular Biology Technology. Cut, Copy, and Paste. Restriction Enzymes. DNA Cloning Is Copying. PCR Is Cloning without the Bacteria. DNA Sequencing. References. 3 Genome Databases. Genome Sequencing. Entrez. BLAST. Genome Annotation. Genome Browser. Human Genetic Diseases. A System for Naming Genes. Model Organisms (Comparative Genomics). Sequencing Other Genomes. References. 4 Bioinformatics Tools. Patterns and Tools. Sequence Comparison. Multiple Alignment. Pattern Finding. Phylogenetics. Biotechnology Exercise. References. 5 Human Genetic Variation. Mutation. Single
Nucleotide Polymorphisms. Linkage. Multigene Diseases. Genetic Testing. SNP Chips. The HapMap Project. Research Uses of SNP Markers. Ethnicity and Genome Diversity. References. 6 Genetic Testing for the Practitioner (Harry Ostrer). Clinical Applications of Genetic Testing. Methods of Genetic Testing. Adequacy of Genetic Testing. Informed Consent. Genetic Counseling. Clinical Vignettes. References. 7 Gene Therapy (John G. Hay). Historical Perspective. Strategies of Gene Therapy. DNA Elements for Gene Expression. Gene Delivery Systems. Targeting Gene Delivery. Formative Years and Initial Clinical Approaches. The Problems. The Future. References. 8 Microarrays. Spotting versus Synthesis on the Chip. Other Types of Arrays. Differential Gene Expression. Error and Reliability. Evolutionary Perspectives. References. 9 Analysis of Microarray Data. Experimental Design. Data Analysis Workflow. Functional Analysis. Validation. References. 10 Pharmacogenomics and Toxicogenomics. Pharmacogenomics. Environmental Chemicals. Toxicogenomics for Drug Development. References. 11 Clinical Research Informatics. Clinical Databases. Clinical Trials Management. Data Standards and Ontologies. Tissue Banks. Application to Medical Practice. References. 12 RNA Interference and MicroRNAs. Antisense RNA. RNA Interference. Ribozymes. References. 13 Alternative Splicing. Exon Arrays. Medical Applications of Alternative Splicing. References. 14 Genome Tiling Chips. Genome Chips. Resequencing Chips. Whole
Genome Transcription Profilig. ChIP
chip. ArrayCGH. References. 15 Cancer Genomics. Understanding Cancer Genomics. Copy Number Mutations. Gene Expression Signatures. Cancer Genome Atlas. References. 16 Proteomics. Protein Modifications. Quantitative Approaches. Biomarkers. Protein Databases. Protein
Protein Interactions. DNA
Binding Proteins. Structural Proteomics. Drug Targets. References. 17 Consumer Genomics and Genealogy. Genealogy. Nutrigenomics. Privacy Concerns. References. 18 The Ethics of Medical Genomics. Eugenics. Human Genome Diversity Project and Population Genetics. Genetic Discrimination. Impact on Physicians and Researchers. Clinical Research. References. Appendix: Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata). Glossary. Index.