Stuart M. Brown, John G. Hay, Harry Ostrer

Essentials of Medical Genomics (eBook, PDF)

• Format: PDF

Produktbeschreibung

* Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays * New edition responds to reviewers' and users' desire for greater coverage--now the most useful handbook on the market! * Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know * Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics * NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook * NEW: PowerPoint slides of images available at instructor website

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 456
• Erscheinungstermin: 7. Januar 2009
• Englisch
• ISBN-13: 9780470334492
• Artikelnr.: 37291728

Autorenporträt

STUART M. BROWN, PhD, is on the faculty of the New York University School of Medicine, where he is Associate Professor and Director of the Bioinfor-matics Core Facility and Director of the graduate Bioinformatics course.

Inhaltsangabe

Preface. 1 Introduction to Molecular Genetics. The Principles of
Inheritance. Genes Are Made of DNA. DNA Structure. The Central Dogma.
References. 2 Molecular Biology Technology. Cut, Copy, and Paste.
Restriction Enzymes. DNA Cloning Is Copying. PCR Is Cloning without the
Bacteria. DNA Sequencing. References. 3 Genome Databases. Genome
Sequencing. Entrez. BLAST. Genome Annotation. Genome Browser. Human Genetic
Diseases. A System for Naming Genes. Model Organisms (Comparative
Genomics). Sequencing Other Genomes. References. 4 Bioinformatics Tools.
Patterns and Tools. Sequence Comparison. Multiple Alignment. Pattern
Finding. Phylogenetics. Biotechnology Exercise. References. 5 Human Genetic
Variation. Mutation. Single-Nucleotide Polymorphisms. Linkage. Multigene
Diseases. Genetic Testing. SNP Chips. The HapMap Project. Research Uses of
SNP Markers. Ethnicity and Genome Diversity. References. 6 Genetic Testing
for the Practitioner (Harry Ostrer). Clinical Applications of Genetic
Testing. Methods of Genetic Testing. Adequacy of Genetic Testing. Informed
Consent. Genetic Counseling. Clinical Vignettes. References. 7 Gene Therapy
(John G. Hay). Historical Perspective. Strategies of Gene Therapy. DNA
Elements for Gene Expression. Gene Delivery Systems. Targeting Gene
Delivery. Formative Years and Initial Clinical Approaches. The Problems.
The Future. References. 8 Microarrays. Spotting versus Synthesis on the
Chip. Other Types of Arrays. Differential Gene Expression. Error and
Reliability. Evolutionary Perspectives. References. 9 Analysis of
Microarray Data. Experimental Design. Data Analysis Workflow. Functional
Analysis. Validation. References. 10 Pharmacogenomics and Toxicogenomics.
Pharmacogenomics. Environmental Chemicals. Toxicogenomics for Drug
Development. References. 11 Clinical Research Informatics. Clinical
Databases. Clinical Trials Management. Data Standards and Ontologies.
Tissue Banks. Application to Medical Practice. References. 12 RNA
Interference and MicroRNAs. Antisense RNA. RNA Interference. Ribozymes.
References. 13 Alternative Splicing. Exon Arrays. Medical Applications of
Alternative Splicing. References. 14 Genome Tiling Chips. Genome Chips.
Resequencing Chips. Whole-Genome Transcription Profilig. ChIP-chip.
ArrayCGH. References. 15 Cancer Genomics. Understanding Cancer Genomics.
Copy Number Mutations. Gene Expression Signatures. Cancer Genome Atlas.
References. 16 Proteomics. Protein Modifications. Quantitative Approaches.
Biomarkers. Protein Databases. Protein-Protein Interactions. DNA-Binding
Proteins. Structural Proteomics. Drug Targets. References. 17 Consumer
Genomics and Genealogy. Genealogy. Nutrigenomics. Privacy Concerns.
References. 18 The Ethics of Medical Genomics. Eugenics. Human Genome
Diversity Project and Population Genetics. Genetic Discrimination. Impact
on Physicians and Researchers. Clinical Research. References. Appendix:
Genetic Testing: Scientific Background for Policymakers (Amanda K. Sarata).
Glossary. Index.