Andrew D. Miller, Julian A. Tanner

Essentials of Chemical Biology

Structure and Dynamics of Biological Macromolecules

• Gebundenes Buch

Produktbeschreibung

An der Schnittstelle von Biologie und Chemie widmet sich die Biochemie der Struktur und Funktion von Biomolekülen - mit zunehmender Bedeutung in der akademischen und kommerziellen Forschung. Dieses Werk eröffnet Studierenden ein Verständnis ihrer grundlegenden Prinzipien.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 592
• Erscheinungstermin: 1. August 2008
• Englisch
• Abmessung: 260mm x 183mm x 36mm
• Gewicht: 1425g
• ISBN-13: 9780470845301
• ISBN-10: 0470845309
• Artikelnr.: 23342419

Autorenporträt

I love children of all ages, and love reading to children. It is such a joy watching them grow, not only physically, but socially and mentally as well. I have worked many years with children and have loved every minute. I am always amazed how fast they learn, and I love being a part of that learning process. I have worked in the classroom and in many summer camps for kids and teens, helping them build confidence and self-esteem to conquer their tasks. I have kids of my own that I have encouraged to succeed and be independent. I love seeing everyone succeed, especially in their courage, certainty, and self-esteem.I love sailing, photography, hiking, camping, scuba diving, motorcycle riding, and spending time with family. If it involves water, outdoors or family, then chances are I love it.

Inhaltsangabe

Preface. Mapping the essentials of chemical biology. Glossary of physical
terms. 1. The structures of biological macromolecules and lipid assemblies.
1.1 General introduction. 1.2 Protein structure. 1.3 Carbohydrate
structure. 1.4 Nucleic acid structure. 1.5 Macromolecular lipid assemblies.
1.6 Structural forces in biological macromolecules. 2. Chemical and
biological synthesis. 2.1 Introduction to synthesis in chemical biology.
2.2 Chemical synthesis of peptides and proteins. 2.3 Chemical synthesis of
nucleic acids. 2.4 Chemical synthesis of oligosaccharides. 2.5 Chemical
synthesis of lipids. 2.6 Biological synthesis of biological macromolecules.
2.7 Directed biological synthesis of proteins. 2.8 Biological syntheses of
nucleic acids, oligosaccharides and lipids. 3. Molecular biology as a
toolset for chemical biology. 3.1 Key concepts in molecular biology. 3.2
Tools and techniques in molecular biology. 3.3 Cloning and identification
of genes in DNA. 3.4 Integrating cloning and expression. 3.5 Site-directed
mutagenesis. 4. Electronic and vibrational spectroscopy. 4.1 Electronic and
vibrational spectroscopy in chemical biology. 4.2 UV-visible spectroscopy.
4.3 Circular dichroism spectroscopy. 4.4 Vibrational spectroscopy. 4.5
Fluorescence spectroscopy. 4.6 Probing metal centres in biological systems
by spectroscopy. 5. Magnetic resonance. 5.1 Magnetic resonance in chemical
biology. 5.2 Key principles of NMR. 5.3 Two-dimensional NMR. 5.4
Multi-dimensional NMR. 5.5 Biological macromolecule structural information.
5.6 EPR spectroscopy; key principles. 6. Diffraction and microscopy. 6.1
Diffraction and microscopy in chemical biology. 6.2 Key principles of X-ray
diffraction. 6.3 Structural information from X-ray diffraction. 6.4 Neutron
diffraction. 6.5 Key principles of electron microscopy. 6.6 Key principles
of scanning probe microscopy. 7. Molecular recognition and binding. 7.1
Molecular recognition and binding in chemical biology. 7.2 Theoretical
models of binding. 7.3 Analysing molecular recognition and binding. 7.4
Biological molecular recognition studies. 8. Kinetics and catalysis. 8.1
Catalysis in chemical biology. 8.2 Steady state kinetic schemes. 8.3
Pre-steady-state kinetics. 8.4 Theories of biocatalysis. 8.5 Electron
transfer. 9. Mass spectrometry and proteomics. 9.1 Mass spectrometry in
chemical biology. 9.2 Key principles in mass spectrometry . 9.3 Structural
analysis of biological macromolecules and lipids by mass spectrometry. 9.4
The challenge of proteomics. 9.5 Genomics - assigning function to genes and
proteins. 10. Molecular selection and evolution. 10.1 Chemical biology and
the origins of life. 10.2 Molecular breeding; natural selection acting on
self-organisation. 10.3 Directed evolution of protein function. 10.4
Directed evolution of nucleic acids. 10.5 Catalytic antibodies.

Rezensionen

"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules. Miller (Imperial College London, UK) and Tanner (Univ. of Hong Kong) cover traditional subjects such as binding interactions and catalysis. They also describe biophysical theories and current methods for protein structure determinations such as circular dichroism, X-ray crystallography, neutron diffraction, NMR, EPR, fluorescence, mass spectrometry, and electron and atomic force microscopy. For example, the chapter on solution NMR provides simplified yet high-quality explanations of the key principles of NMR. The well-developed introduction helps students to better follow the more complex information concerning the principles of multidimensional NMR. In addition, the latter part of the chapter offers current applications using a variety of multidimensional NMR spectroscopy experiments in the analysis of proteins, nucleic acid, carbohydrate, and lipid structures. This reviewer showed Essentials of Chemical Biology to several of his senior graduate students, and they unanimously gave the book rave reviews. The work could be improved by better referencing the resource materials within the text and by providing student exercises at the end of each chapter. Summing Up: Highly recommended. Collections serving graduate students, researchers/faculty, and professionals." -- J. M. Tomich, Kansas State University (Choice, February 2009)

"Essentials in Chemical Biology is a valuable resource not only for chemistry students who are venturing into and interested in biological systems, but also biochemistry and biology students who want a fundamental understanding of the physical and chemical basis of biology and the techniques used in its study." (Chemistry World, August 2009)

"The succinct and lucid presentation style of Essentials Of Chemical Biology will likely make it a popular resource for undergraduate and graduate students interested in the structure and interaction of biologically relevant macromolecules." (Journal of Chemical Biology, February 2009)

"This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules. Miller (Imperial College London, UK) and Tanner (Univ. of Hong Kong) cover traditional subjects such as binding interactions and catalysis. They also describe biophysical theories and current methods for protein structure determinations such as circular dichroism, X-ray crystallography, neutron diffraction, NMR, EPR, fluorescence, mass spectrometry, and electron and atomic force microscopy. For example, the chapter on solution NMR provides simplified yet high-quality explanations of the key principles of NMR. The well-developed introduction helps students to better follow the more complex information concerning the principles of multidimensional NMR. In addition, the latter part of the chapter offers current applications using a variety of multidimensional NMR spectroscopy experiments in the analysis of proteins, nucleic acid, carbohydrate, and lipid structures. This reviewer showed Essentials of Chemical Biology to several of his senior graduate students, and they unanimously gave the book rave reviews. The work could be improved by better referencing the resource materials within the text and by providing student exercises at the end of each chapter." (J. M. Tomich, Kansas State University, Choice, February 2009)