Toren Finkel / J. Silvio Gutkind (Hgg.)

Signal Transduction and Human Disease

Herausgegeben:Finkel, Toren; Gutkind, J. Silvio

• Gebundenes Buch

Produktbeschreibung

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 488
• Erscheinungstermin: 30. Mai 2003
• Englisch
• Abmessung: 260mm x 183mm x 31mm
• Gewicht: 1021g
• ISBN-13: 9780471020110
• ISBN-10: 0471020117
• Artikelnr.: 14919015

Autorenporträt

Dr. Toren Finkel is Chief of the Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health (NIH, DHHS). He received his undergraduate training in physics and then completed a combined M.D./Ph.D. program at Harvard Medical School. Following graduation he pursued an internal medical residency at the Massachusetts General Hospital in Boston and a Cardiology Fellowship at Johns Hopkins School of Medicine in Baltimore. His laboratory has been interested in the role of oxidants as signaling molecules and the participation of free radicals in human disease. Dr. J. Silvio Gutkind is Chief of the Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH, DHHS). He received his Ph.D. in pharmacy and biochemistry from the University of Buenos Aires, Argentina. His laboratory has addressed the molecular basis of cancer by studying normal and aberrant functions of molecules involved in the transduction of proliferative signals. He also leads a multi-institutional effort aimed to elucidate the molecular changes that contribute to the evolution of squamous cell carcinomas.

Inhaltsangabe

Acknowledgments. Contributors. Introduction. 1. Atherosclerosis: Signal
Transduction by Oxygen and Nitrogen Radicals (J. Hill, et al.). 2. NF-κB: A
Key Signaling Pathway in Asthma (S. Levine). 3. Molecular Mechanisms of
Cancer (A. Sodhi, et al.). 4. Apoptotic Pathways in Cancer Progression and
Treatment (J. Chandra & S. Kaufmann). 5. Molecular and Cellular Aspects of
Insulin Resistance: Implications for Diabetes (D. Le Roith, et al.). 6.
Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases (W.
Simonds). 7. Bacterial Regulation of the Cytoskeleton (J. Peck, et al.). 8.
Bacterial Toxins and Diarrhea (W. Patton, et al.). 9. Molecular Basis of
Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways
(R. Visconti, et al.). 10. Mast Cell-Related Diseases: Genetics, Signaling
Pathways, and Novel Therapies (M. Beaven & T. Hundley). 11. Rheumatology
and Signal Transduction (K. Hull & D. Kastner). 12. Molecular Mechanisms of
Neurodegenerative Disorders (B. Wolozin). 13. Neurotrophic Signaling in
Mood Disorders (J. Du, et al.). 14. Inhibiting Signaling Pathways Through
Rational Drug Design (J. Topper & N. Giese). Index.

Rezensionen

"...appropriate for a textbook...pathways and their regulation are well explained and there are helpful tables and illustrations. The information is current and is well referenced...Finkel, Gutkind, and their coauthors have put together examples that illustrate the growing depth of understanding the roles of signal transduction in disease..."
Cell, January 9, 2004