Bio-Glasses (eBook, PDF)

An Introduction
Redaktion: Jones, Julian; Clare, Alexis

• Format: PDF

Produktbeschreibung

This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells. Key features: * First book on biomaterials to focus on bio-glasses * Edited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry Hench * Supported by the International Commission on Glass (ICG) * Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook * Written in an accessible style to facilitate rapid absorption of information * Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures * Of interest to the biomedical as well as the materials science community. The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 254
• Erscheinungstermin: 11. Mai 2012
• Englisch
• ISBN-13: 9781118346471
• Artikelnr.: 37346730

Autorenporträt

Dr Julian Jones is a Senior Lecturer and Royal Academy of Engineering and EPSRC Research Fellow at Imperial College, London. He has 40 peer reviewed publications in leading journals in the field of Biomaterials and has co-edited a leading textbook. His work has been recognised by award of a prestigious Philip Leverhulme Prize in 2007, for excellence in Engineering; the Tissue and Cell Engineering Society (TCES) Early Investigator Award in 2008; and the Institute of Materials, Mining and Minerals (IOM3) Silver Medal, for outstanding achievement in Materials Science and international promotion of the subject. His work has featured in the media with articles in the Daily Mail and Daily Telegraph and an interview on Radio 5 Live. Dr Alexis Clare is Professor of Glass Science at the Inamori School of Engineering, Alfred University, NY, USA.

Inhaltsangabe

List of Contributors xi Foreword xiii Preface xvii 1 The Unique Nature of
Glass 1 Alexis G. Clare 1.1 What is Glass? 1 1.2 Making Glass 5 1.3
Homogeneity and Phase Separation 8 1.4 Forming 9 1.5 Glasses that are not
"Melted" 10 1.6 Exotic Glass 11 1.7 Summary 11 2 Melt-Derived Bioactive
Glass 13 Matthew D. O'Donnell 2.1 Bioglass 13 2.2 Network Connectivity and
Bioactivity 18 2.3 Alternative Bioactive Glass Compositions 19 2.4 In Vitro
Studies 22 2.5 In Vivo Studies and Commercial Products 22 3 Sol-Gel Derived
Glasses for Medicine 29 Julian R. Jones 3.1 Introduction 29 3.2 Why Use the
Sol-Gel Process? 30 3.3 Sol-Gel Process Principles 31 3.4 Steps in a
Typical Sol-Gel Process 32 3.5 Evolution of Nanoporosity 36 3.6 Making
Sol-Gel Monoliths 37 3.7 Making Particles 38 3.8 Sol-Gel Derived Bioactive
Glasses 40 3.9 Summary 42 4 Phosphate Glasses 45 Delia S. Brauer 4.1
Introduction 45 4.2 Making Phosphate Glasses 46 4.3 Phosphate Glass
Structure 46 4.4 Temperature Behaviour and Crystallisation 50 4.5 Phosphate
Glass Dissolution 56 4.6 Cell Compatibility of Glasses 59 4.7 Phosphate
Glass Fibres and Composites 60 4.8 Applications 62 4.9 Summary 63 5 The
Structure of Bioactive Glasses and Their Surfaces 67 Alastair N. Cormack
5.1 Structure of Glasses 67 5.2 Structure of Bioactive Glasses 70 5.3
Computer Modeling (Theoretical Simulation) of Bioactive Glasses 71 5.4
Glass Surfaces 74 5.5 Summary 76 6 Bioactive Borate Glasses 77 Steven B.
Jung 6.1 Introduction 77 6.2 What Differentiates a Bioactive Borate Glass
from Other Bioactive Glasses? 78 6.3 Evaluating Reactive Materials ( 6.4
Multifunctional Bioactive Borate Glasses 83 6.5 Applications of Bioactive
Borate Glasses in Orthopedics and Dental Regeneration 86 6.6 Soft Tissue
Wound Healing 88 6.7 Tissue/Vessel Guidance 92 6.8 Drug Delivery 93 6.9
Commercial Product Design 94 6.10 Summary 96 7 Glass-Ceramics 99 Wolfram
Holand 7.1 Glass-Ceramics and Their Uses 99 7.2 Methods Used for the
Controlled Crystallization of Glasses 101 7.3 A Glass-Ceramic that Hardly
Expands When Heated 103 7.4 High-Strength, Moldable Glass-Ceramics for
Dental Restoration 104 7.5 Glass-Ceramics that are Moldable and Machinable
106 7.6 Outlook 106 8 Bioactive Glass and Glass-Ceramic Coatings 109 Enrica
Verne 8.1 Introduction 109 8.2 Enameling 110 8.3 Glazing 114 8.4 Plasma
Spraying 117 8.5 Radiofrequency Magnetron Sputtering Deposition 119 8.6
Pulsed Laser Deposition 119 8.7 Summary 120 9 Composites Containing
Bioactive Glass 123 Aldo R. Boccaccini and Qi-Zhi Chen 9.1 Introduction 123
9.2 Biodegradable Polymers 127 9.3 Composite Scaffolds Containing Bioactive
Glass 131 9.4 Processing Technologies for Porous Bioactive Composites 133
9.5 Case Study: the PDLLA-Bioglass Composite Scaffold System 138 9.6 Final
Remarks 139 10 Inorganic-Organic Sol-Gel Hybrids 141 Yuki Shirosaki,
Akiyoshi Osaka, Kanji Tsuru, and Satoshi Hayakawa 10.1 Introduction 141
10.2 Hybrids in Medicine and Why They Should Be Silica-Based 142 10.3
Self-Assembled Hybrid Films and Layers of Grafted Silanes 145 10.4 Sol-Gel
Hybrids 146 10.5 Ormosils 148 10.6 Polymer Choice and Property Control in
Hybrids 151 10.7 Maintaining Bioactivity in Sol-Gel Hybrids 154 10.8
Summary and Outlook 158 11 Dental Applications of Glasses 161 Leena Hupa
and Antti Yli-Urpo 11.1 Introduction 161 11.2 Structure of the Human Tooth
162 11.3 Glass Bioactivity and Teeth 163 11.4 Bioactive Glass in Dental
Bone Regeneration 166 11.5 Treatment of Hypersensitive Teeth 168 11.6
Bioactive Glass Coating on Metal Implants 169 11.7 Antimicrobial Properties
of Bioactive Glasses 172 11.8 Bioactive Glasses in Polymer Composites 173
11.9 Bioactive Glasses in Glass Ionomer Cements 174 11.10 Summary 175 12
Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue
Engineering 179 Julian R. Jones 12.1 Introduction 179 12.2 Synthetic Bone
Grafts and Regenerative Medicine 181 12.3 Design Criteria for an Ideal
Synthetic Bone Graft 183 12.4 Bioglass and the Complication of
Crystallisation During Sintering 184 12.5 Making Porous Glasses 185 12.6
The Future: Porous Hybrids 196 12.7 Bioactive Glasses and Tissue
Engineering 200 12.8 Regulatory Issues 201 12.9 Summary 202 13 Glasses for
Radiotherapy 205 Delbert E. Day 13.1 Introduction 205 13.2 Glass Design and
Synthesis 208 13.3 Non-Degradable or Bio-inert Glasses: Rare Earth
Aluminosilicate Glasses 208 13.4 Biodegradable Glasses: Rare Earth
Borate/Borosilicate Glasses 211 13.5 Design of Radioactive Glass
Microspheres for In Vivo Applications 213 13.6 Treatment of Liver Cancer:
Hepatocellular Carcinoma 217 13.7 Treatment of Kidney Cancer: Renal
Cellarcinoma 222 13.8 Treatment of Rheumatoid Arthritis:
RadiationSynovectomy 223 13.9 Summary 227 References 228 Index 231