Amitava Dasgupta

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring (eBook, PDF)

A Comprehensive Guide

• Format: PDF

Produktbeschreibung

The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: * False positive results in immunoassays for drugs in abuse testing * Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin * False positive alcohol tests using breath analyzers and automated analyzers * When a toxicology report is negative in a suspected overdose patient: the world of designer drugs * Effects of drug-herb interactions on therapeutic drug monitoring * Pharmacogenomics and the general principles of genetic analysis * Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing * What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 472
• Erscheinungstermin: 9. Juli 2012
• Englisch
• ISBN-13: 9781118347836
• Artikelnr.: 37352313

Autorenporträt

AMITAVA DASGUPTA is a Professor in the Department of Pathology and Laboratory Medicine at the University of Texas Medical School at Houston and the director of clinical chemistry, toxicology, and point of care testing at the Memorial Hermann Hospital. He is the author of Herbal Supplements and Pharmacogenomics in Clinical Therapeutics, both published by Wiley.

Inhaltsangabe

Preface vii Chapter 1 An Introduction to Tests Performed in Toxicology
Laboratories 1 Chapter 2 Challenges in Drugs of Abuse Testing 31 Chapter 3
False-Positive Results Using Immunoassays for Drugs of Abuse Testing 53
Chapter 4 True-Positive Drugs of Abuse Test Results Due to Use of
Prescriptions and Nonprescription Drugs 67 Chapter 5 When Toxicology Report
Is Negative in a Suspected Overdosed Patient: The World of Designer Drugs
85 Chapter 6 Abuse of Magic Mushrooms, Peyote Cactus, Khat, and Solvents:
No Readily Available Laboratory Tests 101 Chapter 7 Limitations of Blood
Alcohol Measurements Using Automated Analyzers and Breath Analyzers 121
Chapter 8 Role of the Laboratory in Detecting Other Poisoning, Including
Pesticides, Ethylene Glycol, and Methanol 139 Chapter 9 Poisoning with
Warfarin and Superwarfarin: What Can Laboratory Testing Do? 161 Chapter 10
Plant Poisoning and the Clinical Laboratory 185 Chapter 11 Sources of
Erroneous Results in Therapeutic Drug Monitoring Due to Preanalytical
Errors, High Bilirubin, Hemolysis, and Lipids 213 Chapter 12 Challenges in
Therapeutic Drug Monitoring of Digoxin Using Immunoassays 237 Chapter 13
Interference in Immunoassays Used for Monitoring Anticonvulsants and the
Usefulness of Monitoring Free Anticonvulsants 265 Chapter 14 Interference
in Immunoassays Used to Monitor Tricyclic Antidepressants 293 Chapter 15
Therapeutic Drug Monitoring of Immunosuppressants: Limitations of
Immunoassays and the Need for Chromatographic Methods 323 Chapter 16 Effect
of Drug-Herb Interactions on Therapeutic Drug Monitoring 355 Chapter 17
Pharmacogenomics and the Toxicology Laboratory 385 Chapter 18 Approaches
for Eliminating Interference/Discordant Specimens in Therapeutic Drug
Monitoring and Drugs of Abuse Testing 411 Index 429